| SKN1 deletion | Chronological lifespan increased by 60% for single skn1 and double ipt1-skn1 deletion [16527275]. | Yeast | +60 | — | — |
| TOS8 | Deletion of TOS8 increases replicative lifespan increased by 35% in the alpha strain [18340043]. | Yeast | +35 | — | — |
| WSC4 deletion | Deletion of WSC4 decreases replicative lifespan by 30% in the alpha strain [18340043]. | Yeast | -30 | — | — |
| YHF1 deletion | Deletion of YFH1 decreases replicative lifespan by 50% [15130665]. | Yeast | -50 | — | — |
| YHC3 deletion | YHC3 deletion decreases 10-20% shortened lifespan [16435200]. | Yeast | -10 to -20 | — | — |
| YIA6 deletion | Deletion of YIA6 decreases replicative lifespan by 30% in the a strain [18340043]. | Yeast | -30 | — | — |
| YOS9 deletion | Deletion of YOS9 decreases replicative lifespan by 10% in the alpha strain [19030232]. | Yeast | -10 | — | — |
| YPC1 deletion | Deletion of YPC1 decreases replicative lifespan by 15% in the alpha strain [19030232]. | Yeast | -15 | — | — |
| YPK1 deletion | Deletion of YPK1 decreases replicative lifespan by 20% in the alpha strain [18340043]. | Yeast | -20 | — | — |
| YUH1 deletion | Deletion of YUH1 decreases replicative lifespan decreased 30% in the alpha strain [18340043]. | — | -30 | — | — |
| YVH1 deletion | Deletion of YVH1 increases replicative lifespan by 50% in the alpha strain [18340043]. | Yeast | +50 | — | — |
| Hsp22 transposition | Animals that do not express Hsp22 (due to a transposition into its transcriptional starting site) have a 40% decrease in lifespan, exhibit a 30% decrease in locomotor activity and are sensitive to mild stress [20036725]. | Fly | -40 | — | — |
| C26B2.2 knockout | C26B2.2 knockout mutations extend lifespan [15253933]. | Worm | — | — | — |
| Atg7 knockout | Knockouts of Atg7 are short-lived with a 30% reduction in maximum lifespan and are hypersensitive to nutrient and oxidative stress [18056421; 19550147]. | Fly | — | — | -30 |
| asg-2 mutation | Knockout mutations in asg-2 result in developmental arrest and increased lifespan [11410594]. | Worm | — | — | — |
| OSH3 deletion | Mean replicative lifespan of OSH3 deletion mutant is not significant different from wild type [Fusheng, unpublished]. | Yeast | — | — | — |
| GAD1 deletion | GAD1 deletion extends replicative lifespan [21371425]. | Yeast | — | — | — |
| UGA4 deletion | Deletion of UGA4 does not effect replicative lifespan [21371425]. | Yeast | — | — | — |
| CTF8 deletion | Deletion of CTF8 increases mean chronological lifespan by 15-92% (15, 18, 42, 45, 92) in diploid cells [21447998]. | Yeast | +15 to +92 | — | — |
| LEU3 deletion | LEU3 deletion dramatically increases chronological lifespan [19302372]. | Yeast | — | — | — |
| YSC84 deletion | Deletion of YSC84 increases replicative lifespan by 20% in the alpha strain [19030232]. YSC84 deletion increases replicative lifespan by 25% in the alpha strain [18340043]. | Yeast | +20 to +25 | — | — |
| YPT6 deletion | Deletion of YPT6 increases replicative lifespan by 20% [19030232]. YPT6 deletion increases replicative lifespan by 30% in the alpha strain and by 10% in the a strain [18340043]. | Yeast | +10 to +30 | — | — |
| YME1 deletion | Deletion of YME1 decreases chronological lifespan by 50% [17492370] as well as replicative lifespan by 45% in the alpha strain [18340043]. | Yeast | -45 to -50 | — | — |
| VHS1 deletion | Deletion of VHS1 increases replicative lifespan [16293764]. VHS1 deletion increases replicative lifespan by 60% in the alpha strain [19030232]. | Yeast | +60 | — | — |
| VAM3 deletion | Deletion of VAM3 decreases mean replicative lifespan by 56% both on AL [19030232] and on moderate DR [18690010] (in BY4742/alpha strain). | Yeast | -56 | — | — |
GenAge
GenDR
