| VAC14 deletion | VAC14 mutants have a single vacuole and shortened lifespan on normal media [16293764]. | Yeast | — | — | — |
| ZDS1 deletion | Deletion of ZDS1 increases replicative lifespan by 37% in a SIR3-dependent manner [10662670].
Null mutation in ZDS1 causes 100-fold decrease in telomeric silencing, a nine-fold increase in rDNA silencing, reduces rDNA recombination, and decreases Sir3 phosphorylation [10662670]. | Yeast | +37 | — | — |
| SKN1 deletion | Chronological lifespan increased by 60% for single skn1 and double ipt1-skn1 deletion [16527275]. | Yeast | +60 | — | — |
| TOS8 | Deletion of TOS8 increases replicative lifespan increased by 35% in the alpha strain [18340043]. | Yeast | +35 | — | — |
| WSC4 deletion | Deletion of WSC4 decreases replicative lifespan by 30% in the alpha strain [18340043]. | Yeast | -30 | — | — |
| YHF1 deletion | Deletion of YFH1 decreases replicative lifespan by 50% [15130665]. | Yeast | -50 | — | — |
| YHC3 deletion | YHC3 deletion decreases 10-20% shortened lifespan [16435200]. | Yeast | -10 to -20 | — | — |
| YIA6 deletion | Deletion of YIA6 decreases replicative lifespan by 30% in the a strain [18340043]. | Yeast | -30 | — | — |
| YOS9 deletion | Deletion of YOS9 decreases replicative lifespan by 10% in the alpha strain [19030232]. | Yeast | -10 | — | — |
| YPC1 deletion | Deletion of YPC1 decreases replicative lifespan by 15% in the alpha strain [19030232]. | Yeast | -15 | — | — |
| YPK1 deletion | Deletion of YPK1 decreases replicative lifespan by 20% in the alpha strain [18340043]. | Yeast | -20 | — | — |
| YUH1 deletion | Deletion of YUH1 decreases replicative lifespan decreased 30% in the alpha strain [18340043]. | — | -30 | — | — |
| YVH1 deletion | Deletion of YVH1 increases replicative lifespan by 50% in the alpha strain [18340043]. | Yeast | +50 | — | — |
| Hsp22 transposition | Animals that do not express Hsp22 (due to a transposition into its transcriptional starting site) have a 40% decrease in lifespan, exhibit a 30% decrease in locomotor activity and are sensitive to mild stress [20036725]. | Fly | -40 | — | — |
| C48E7.2 RNAi | RNA interference of C48E7.2 in adulthood results in a 26% increase in mean lifespan [17521386]. | Worm | +26 | — | — |
| C26B2.2 knockout | C26B2.2 knockout mutations extend lifespan [15253933]. | Worm | — | — | — |
| Atg7 knockout | Knockouts of Atg7 are short-lived with a 30% reduction in maximum lifespan and are hypersensitive to nutrient and oxidative stress [18056421; 19550147]. | Fly | — | — | -30 |
| asg-2 mutation | Knockout mutations in asg-2 result in developmental arrest and increased lifespan [11410594]. | Worm | — | — | — |
| akt-1 RNAi | RNA interference of akt-1 leads to lifespan extension [15998808]. | Worm | — | — | — |
| aco-2 RNAi | RNA interference of aco-2 leads to lifespan extension [15998808]. | Worm | — | — | — |
| OSH3 deletion | Mean replicative lifespan of OSH3 deletion mutant is not significant different from wild type [Fusheng, unpublished]. | Yeast | — | — | — |
| GAD1 deletion | GAD1 deletion extends replicative lifespan [21371425]. | Yeast | — | — | — |
| UGA4 deletion | Deletion of UGA4 does not effect replicative lifespan [21371425]. | Yeast | — | — | — |
| CTF8 deletion | Deletion of CTF8 increases mean chronological lifespan by 15-92% (15, 18, 42, 45, 92) in diploid cells [21447998]. | Yeast | +15 to +92 | — | — |
| Sirt6 knockout | Sirt6 knockout mice develop signs of premature ageing including a short lifespan [16439206].
Mice without Sirt6 have a higher risk of gastrointestinal cancers. Loss of Sirt6 increases the number, size and aggressiveness of tumors. Sirt6 loss leads to tumor formation even without activation of oncogenes. Transformed SIRT6-deficient cells exhibit increased glycolysis and tumor growth [23217706].
| Mouse | — | — | — |
GenAge
GenDR
