Interventions

  • name effect species mean median maximum
    Hsp22 transposition Animals that do not express Hsp22 (due to a transposition into its transcriptional starting site) have a 40% decrease in lifespan, exhibit a 30% decrease in locomotor activity and are sensitive to mild stress [20036725]. Fly -40
    IPT1 transposition Transposon-mediated mutation of IPT1 increases oxidative stress resistance and chronological lifespan by 40% [16527275]. Yeast +40
    SCH9 Transposition Transposon-mediated mutagenesis of SCH9, which encodes for a serine threonine kinase homologous to Akt/PKB, increases resistance to oxidants and thermal stress as well as extends chronological lifespan by 30% [11292860]. Yeast +30
    CYR1 transposition Transposon-mutagenized CYR1 increases resistance to oxidants and extends chronological lifespan by up to 90%. Stress-resistance transcription factors Msn2/Msn4 and protein kinase Rim15 are required for this lifespan extension [11292860]. Yeast +300
    insc transposition insc disruption through an insertion of the P{EPgy2} vector in ts structural part prolongs female lifespan [22661237]. Fly
    esg transposition Disruption of esg by insertion of the P{GT1} vector 300 bp downstream of its structural part increases male and female lifespan [22661237]. Fly
    aPKC transposition Insertion of a P-based vectors in the structural part of aPKC increase male and female lifespan [22661237]. Fly
    • 7 interventions
    Interventions are an extension of GenAge and GenDR.