rab-10 RNAi

Species: Nematode (Taxid: 6239)
Factor: rab-10
Manipulation: Loss-of-Function, Knockdown, RNA Interference
Effect:

rab-10 RNA interference significantly extends lifespan of wild-type by 14 - 16%, of daf-16 mutants by 47%, and of daf-2 by 46%, but fails to significantly further extend lifespan of eat-2 mutants. rab-10 RNAi does not affect pumping, but similar to DR reduces and delays reproduction as well as cause a slender appearance. rab-10 RNAi significantly reduces paralysis in Q35YFP transgenic animals [18331616].

Mean: +14 to +16

Aging Relevance Analysis/Source:
  • GenAge
  • GenDR



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