Denigma

ZDS2 deletion

Species: Budding yeast (Taxid: 4932)
Factor: ZDS2
Manipulation: Loss-of-Function, Knockout, Mutation, Deletion
Effect:

Deletion of ZDS2 decreases replicative lifespan by about 20% [10662670].

ZDS2 null mutation decreases rDNA silencing five-fold, increases silencing at a mutnat HMR that lacks the Rap1-binding site i the HNR-E silencer three-fold, and has no effect on telomeric silencing. ZDS2 deletion decreases rDNA silencing, increases rDNA recombination, and increases level of phosphorylated Sir3 [10662670].

Mean: -20

Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

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