Spermidine

Factor: Spd
Manipulation:
Effect:

Administration of spermidine extends lifespan of yeast, flies and worms and human immune cells. In yeast spermidine treatment triggers deacetylation of H3 through inhibition of histone acetylatranserfases, suppresses oxidative stress and necrosis. Altered acetylation of the chromatin results in upregulation of various autophagy-related genes and triggers autophagy [19801973].


References:
  • 19801973: Induction of autophagy by spermidine promotes longevity.




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