unc-31 mutation

Species: Nematode (Taxid: 6239)
Factor: unc-31
Manipulation: Loss-of-Function, Knockout, Mutation
Effect:

Mutation in unc-31 increases hermaphrodite lifespan by approximately 70% and male lifespan by 150% [10377425; 11063684; 10747056]. unc-31 also cause constitutive dauer formation. Both phenotypes, enhanced longevity and constitutive dauer formation are suppressed by mutations in daf-16 [10377425].

unc-31 mutants are uncoordinated [4366476] and exhibit dauer constitutive phenotype [10377425], are lethargic, feed constitutively, are defective in egg-laying, and produce dauer larvae that fail to recover [8462849].

Mean: +70 to +150

Aging Relevance Analysis/Source:
  • GenAge
  • GenDR



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