Denigma

Overexpression of truncated TLC1

Species: Budding yeast (Taxid: 4932)
Factor: TLC1
Manipulation: Loss-of-Function, Overexpression, Mutation
Effect:

Overexpression of a truncated allele of TLC1 abrogates telomere silencing [7545955], shortened telomeres and extends replicative lifespan approximately by 20% [9275199]. Deletion of TLC1 might decrease replicative lifespan [Nugent et al., 1996].

Mean: +20

Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

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