Denigma

SUN4 deletion

Species: Budding yeast (Taxid: 4932)
Factor: SUN4
Manipulation: Loss-of-Function, Knockout, Mutation, Deletion
Effect:

Disruption of SUN4 shortens mean (87.5% of normal), but not maximum, replicative lifespan in BKY1-14c [Austriaco, N.R. (1996) “UTH1 and the Genetic Control of Aging in the Yeast, Saccharomyces cerevisiae.” Ph.D. Thesis, Massachusetts Institute of Technology; 8810036]

SUN4 mutation causes failure of daughter cells to completely detach and results in a multi-budded morphology [10683261].

Mean: -12.5

Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

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