Sod2 overexpression

Species: Fruit fly (Taxid: 7227)
Factor: Sod2
Manipulation: Gain-of-Function, Overexpression
Effect:

Overexpression of Sod2 by 5-115% decreases lifespan by 4-5% without any compensatory changes in metablic rate, level of physical activity, or the levels of other antioxidants (Sod, Cat, and glutathione) [10545213]. Targeted overexpression of Sod2 in motor neurons alone extends lifespan by 30% [11113599]. Induced overexpression of Sod2 in adult animals extends lifespan up to 37% [12072463]. Overexpression of catalase in combination with SOD2 has no added benefit for lifespan [12072463]. Animals overexpressing SOD2 or catalase do not exhibit a decrease in metabolism as measured by oxgen consumption [12072463].

Sod2 overexpression results in a 20% increase in mean and maximum lifespan [18067683].

Mean: +20 to +37
Maximum: +20

References:
  • 10545213: Overexpression of Mn-containing superoxide dismutase in transgenic Drosophila melanogaster.
  • 12072463: Induced overexpression of mitochondrial Mn-superoxide dismutase extends the life span of adult Drosophila melanogaster.
  • 11113599: Targeted neuronal gene expression and longevity in Drosophila.
  • 18067683: Transcriptional profiling of MnSOD-mediated lifespan extension in Drosophila reveals a species-general network of aging and metabolic genes.


  • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR



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