Denigma

Sod2 overexpression

Species: House mouse (Taxid: 10090)
Factor: Sod2
Manipulation: Gain-of-Function, Overexpression
Effect:

Two-fold overexpression of Sod2 in young (4-6 months) and old (26-28 months) throughout the life results in decreased lipid peroxidation, increased resistance against paraquat-induced oxidative stress, and decreased age-related decline in mitochondrial ATP production, without any change on lifespan or age-related pathology [19633237].


References:
  • 19633237: Overexpression of Mn superoxide dismutase does not increase life span in mice.


    • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

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