Denigma

SOD1 overexpression

Species: Budding yeast (Taxid: 4932)
Factor: SOD1
Manipulation: Gain-of-Function, Overexpression
Effect:

The overexpression of Sods, mitochondrial Sod2 and cytosolic CuZnSod (Sod1), in combination delays the age-dependent reversible inactivation of mitochondrial aconitase, a superoxide-sensitive enzyme, and extends chronological lifespan by 30% [12586694]. Overexpression of SOD1 with CCS1 levuates the level of Cn, Zn-Sod activity and increased chronological lifespan. However overexpression of SOD1 without high cooper or simultonous overexpression of CCS1 shortened both chronological and replicative lifespan [15659212]. Overexpression of SOD1 has no effect on replicative lifespan [10224252].


Aging Relevance Analysis/Source:
  • GenAge
  • GenDR
    • Comparisons:
  • sod1 vs. wild-type ( 30°C ) : -84.4(mean) -86.4(median) -70.9(max) 6.71e-32(p-value)

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