sir4-42 mutation

Species: Budding yeast (Taxid: 4932)
Factor: SIR4
Manipulation: Mutation
Effect:

The sir4-42 mutation extends lifespan of by more than 30% and is semidominant in Bx1-14c strain which carrys a C-terminal truncation of MPT5/UTH4. sir4-42 extends lifespan by preventing recruitment of the SIR proteins to HM loci and telomeres, thereby increasing their concentration at other chromosomal regions. Expression of only the carboxyl terminus of SIR4 interferes with silencing at HM loci and telomere, which also extends lifespan [7859289]. Both Sir3 and Sir4 relocate to the nucleolus in the sir4-42 mutant background, dependent upon MPT5 and YGL023. sir4-42 has no effect on lifespan in a UTH4 wild-type strain background [9150138]. sir-4-42 results in constitutive localization of SIR3 to the rDNA. Lifespan extension by sir4-42 is likely due to increased dosage of SIR2 at the rDNA [10521401].

References:

7859289: Mutation in the silencing gene SIR4 can delay aging in S. cerevisiae.

9150138: Redistribution of silencing proteins from telomeres to the nucleolus is associated with extension of life span in S. cerevisiae.

Aging Relevance Analysis/Source:

GenAge

GenDR

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