Downregulation of scl-1 by RNAi reduces slightly but reproducibly lifespan as well as stress resistance, similar to the effect of mutation in daf-16. scl-1 RNAi prevents lifespan extension associated with mutation of daf-2 or age-1 [12620193].
RNAi of scl-1 causes hat shock and UV sensitivity [12620193].
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GenDR
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