Rgn knockout

Species: House mouse (Taxid: 10090)
Factor: Rgn
Manipulation: Loss-of-Function, Knockout, Mutation, Deletion
Effect:

Survival among make animals lacking Rgn (alias SMP30) is 50% at 180 days compared to 100% among controls [N. Maruyama, unpublished data].

SMP30-/- mutant mice are indstuguishibale form their SMP30+/+ littermates in terms of development and fertilization capacity [12368201]. However, -/- mice were more susceptible to liver injury after treatment with anti-FAS antibody. SMP30-/- hepatocytes cultures in vitro are more susceptible to apoptosis induced by tumor-necrosis factor (TNF-alpha) plus actinomycin D (ActD) than SMP30+/+ hepatocytes.


Aging Relevance Analysis/Source:
  • GenAge
  • GenDR



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