Deletion of mitochondrial DNA

Species: Budding yeast (Taxid: 4932)
Factor:
Manipulation:
Effect:

Activation of the retrograde response by deletion of mitchondrial DNA (rho0) extends mean and maximum replicative lifespan by 24 - 51% and 15 - 65%, respectively [10224252]. Lifespan extension associated with impaired mitochondria depends on a retrograde intracellular signalling involving at leas three transcription factors, which adjust nuclear gene expression an induce shift of metabolism from Krebs cycle to the glyoxylate cycle [Refs 41,42 i Lee et al., 2002].

Mean: +24 to +51
Maximum: +15 to +65

References:
  • 10224252: Interorganelle signaling is a determinant of longevity in Saccharomyces cerevisiae.




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