puc mutation

Species: Fruit fly (Taxid: 7227)
Factor: puc
Manipulation: Loss-of-Function, Knockout, Mutation
Effect:

Heterozygous loss-of-function mutations in puc (either pucA241.1 or pucE69) significantly extend median and maximum lifespan and increase resistance to oxidative stress. Heterzyogosity for puc only modestly extends lifespan in animals carrying a hypomorphic allele of the JNK kinase hep [14602080].

puc heterzyogotes do not differ signficantly from wild-type for body size, reproductive activity or developmental timing, but exhibit increased resistance to oxidative stress and starvation [14602080].


Aging Relevance Analysis/Source:
  • GenAge
  • GenDR



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