Denigma

Plau overexpression

Species: House mouse (Taxid: 10090)
Factor: Plau
Manipulation: Gain-of-Function, Overexpression
Effect:

Transgenic mice (called alphaMUPA) overexpression Plau in many brain sites (including hypothalamus) consume (20%) less food, have a reduced body weight (by 20%) and length (by 6%), reduced temperature, and a prolonged lifespan (by 20%) [9060969].

alphaMUPA mice have reduced levels of blood sugar and smaller size and birth frequency compared to parental control [9060969] as well as a reduced body weight [10638529].

Mean: +20

References:
  • 9060969: Transgenic mice overexpressing urokinase-type plasminogen activator in the brain exhibit reduced food consumption, body weight and size, and increased longevity.


    • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

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