pept-2 mutation

Species: Nematode (Taxid: 6239)
Factor: pept-1
Manipulation: Loss-of-Function, Knockout, Mutation, Deletion
Effect:

Deletion of pept-1 (alias opt-2 or pep-2) results in retarded development, reduced body size and extended reproductive lifespan. It also further extends (60%) the life-extension caused by daf-2 mutations [15155758].

pept-2 mutants exhibit a decrease in fat content.


References:
  • 15155758: Deletion of the intestinal peptide transporter affects insulin and TOR signaling in Caenorhabditis elegans.


  • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR



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