Denigma

pdk-1 mutation

Species: Nematode (Taxid: 6239)
Factor: pdk-1
Manipulation: Loss-of-Function, Knockout, Mutation
Effect:

Loss-of-function alleles in pdk-1 extend lifespan by 60% [10364160].

pdk-1(sa680) mutants are dauer constitutive (suppressed by daf-16) [10364160].

Mean: +60

References:
  • 10364160: A PDK1 homolog is necessary and sufficient to transduce AGE-1 PI3 kinase signals that regulate diapause in Caenorhabditis elegans.


    • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

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