Denigma

Homozygous Shc1 knockout

Species: House mouse (Taxid: 10090)
Factor: Shc1
Manipulation: Loss-of-Function, Knockout, Mutation, Deletion
Effect:

Homozygous Shc1 knockout mice have an 28% increase in mean lifespan [10580504].

p66shc-/- cells are more resistant to apoptosis induced by hydrogen peroxide and UV light. p66shc-/- mice aremore restante to oxidative stress induced by paraquat [10580504].

Mean: +28

References:
  • 10580504: The p66shc adaptor protein controls oxidative stress response and life span in mammals.


    • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

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