osm-3 mutation

Species: Nematode (Taxid: 6239)
Factor: osm-3
Manipulation: Loss-of-Function, Knockout, Mutation
Effect:

Recessive osm-3 loss-of-function alleles can extend lifespan by 100%, which is suppressed by gonad ablation but not germ line ablation [10617200].

osm-3 mutants do not form dauers in response to starvation and have defective cilia [1732156] as well as are defective in chemosensory response and chemotaxis [7714894].

Mean: +100

References:
  • 10617200: Regulation of lifespan by sensory perception in Caenorhabditis elegans.
  • 1732156: Genetic analysis of chemosensory control of dauer formation in Caenorhabditis elegans.
  • 7714894: Exclusive expression of C. elegans osm-3 kinesin gene in chemosensory neurons open to the external environment.


  • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR



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