Denigma: Intervention

NPT1 deletion

Species: Budding yeast (Taxid: 4932)
Factor: NPT1
Manipulation: Loss-of-Function, Knockout, Mutation, Deletion
Effect:

NPT1 deletion decreases replicative lifespan by 50% [17482543] as well as chronological lifespan [17110466]. Deletion of NPT1 shortens the lifespan in W303R. Replicative lifespan extension of cdc25-10 mutation (assumed to act as a genetic DR-mimetic) is cancelled out by NPT1 deletion [11000115].

NPT1 mutation results in loss of telomere and rDNA silencing [10841563], an effect that is likely caused by a loss of SIR2 activty due to decreased NAD levels. Mutation of NPT1 is synthetical lethal with mutation of QPT1 [11000115].

Mean: -50

References:

11000115: Requirement of NAD and SIR2 for life-span extension by calorie restriction in Saccharomyces cerevisiae.

17482543: Nicotinamide riboside promotes Sir2 silencing and extends lifespan via Nrk and Urh1/Pnp1/Meu1 pathways to NAD+.

17110466: Dihydrolipoyl dehydrogenase as a source of reactive oxygen species inhibited by caloric restriction and involved in Saccharomyces cerevisiae aging.

10841563: A phylogenetically conserved NAD+-dependent protein deacetylase activity in the Sir2 protein family.

Aging Relevance Analysis/Source:

GenAge