MSN2 MSN4 double mutation

Species: Budding yeast (Taxid: 4932)
Factor: MSN2 MSN4
Manipulation: Loss-of-Function, Knockout, Mutation, Deletion
Effect:

Deletion of MSN2 and MSN4 extends replicative lifespan and is further extended by cyr1::mTn [14741356]. Deletion of MSN2 and MSN4 does not significantly decrease chronological lifespan under AL, but attenuates chronological lifespan extension by water starvation and 0.5% glucose restriction [18225956] as well as cancels out lifespan extension of cyr1::mTn [14741356] and decreases chronological lifespan extension of ras2 deletion mutant [12586694]. Simulatnous deletion of MSN2 and MSN4 has no effect on chronological lifespan, but prevents lifespan extension by RAS2 deletion [12586694]. msn2 msn4 has no effect on replicative lifespan in PSY316, and does not prevent lifespan extension by DR [11000115] or by high osmolarity [12391171].


References:
  • 12586694: SOD2 functions downstream of Sch9 to extend longevity in yeast.
  • 11000115: Requirement of NAD and SIR2 for life-span extension by calorie restriction in Saccharomyces cerevisiae.
  • 12391171: High osmolarity extends life span in Saccharomyces cerevisiae by a mechanism related to calorie restriction.
  • 14741356: Chronological aging-independent replicative life span regulation by Msn2/Msn4 and Sod2 in Saccharomyces cerevisiae.
  • 18225956: Life span extension by calorie restriction depends on Rim15 and transcription factors downstream of Ras/PKA, Tor, and Sch9.


  • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

  • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR



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