Denigma: Intervention

MPT5 deletion

Species: Budding yeast (Taxid: 4932)
Factor: MPT5
Manipulation: Loss-of-Function, Knockout, Mutation, Deletion
Effect:

Deletion of MPT5 shortens replicative lifespan by about 50% [9150138; 7859289]. MPT5 deletion decreases average chronological lifespan by 50%, which is rescued to the wild-type level by PKC1 overexpression [17172436].

MPT5 mutants are temperature sensitive [7845352], hypersensitive to mating pheromone [9154842], and null mutants exhibit increased silencing at telomeres and decreased rDNA silencing [9584615]. Deletion of MPT5 is synthetical lethal with mutation of either SWI4, SWI6, or CCR4 in an ssd1-d background [11805047]. MPT5 is required for relocalization of the SIR complex to the nucleolus in sir4-42 strain [7859289].

Mean: -50

References:

11805047: Saccharomyces cerevisiae MPT5 and SSD1 function in parallel pathways to promote cell wall integrity.

17172436: Mpt5p, a stress tolerance- and lifespan-promoting PUF protein in Saccharomyces cerevisiae, acts upstream of the cell wall integrity pathway.

7845352: A new yeast gene, HTR1, required for growth at high temperature, is needed for recovery from mating pheromone-induced G1 arrest.

9584615: Molecular mechanisms of yeast aging.

7859289: Mutation in the silencing gene SIR4 can delay aging in S. cerevisiae.

9150138: Redistribution of silencing proteins from telomeres to the nucleolus is associated with extension of life span in S. cerevisiae.

Aging Relevance Analysis/Source:

GenAge