Overexpression of mitochondrial targeted CAT

Species: House mouse (Taxid: 10090)
Factor: CAT
Manipulation: Gain-of-Function, Overexpression
Effect:

Overexpression of human catalase targeted to mitochondria (MCAT) extends mean and maximum lifespan by about 20% in mice. Inactivation of aconitase in heat mitochondria and mitochondrial damage is also reduced in long-lived CAT mutant mice [15879174].

The MCAT strain has a reduced severity of age-dependent arteriosclerosis and increased genomic stability, as indicated by an decrease in oxidative stress and mitochondrial deletions in heart and muscle tissues. Median and maximum lifespan in increased about 17 - 21% [16144468].

Mean: +20
Median: +17 to +21
Maximum: +17 to +21

References:
  • 15879174: Extension of murine life span by overexpression of catalase targeted to mitochondria.
  • 16144468: Oxidative stress and aging: catalase is a longevity determinant enzyme.


  • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR



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