Denigma

mes-1 mutation

Species: Nematode (Taxid: 6239)
Factor: mes-1
Manipulation: Loss-of-Function, Knockout, Mutation
Effect:

mes-1(bn7) mutant animals that lack germ cells live about 60% longer than fertile mes-1(bn7) controls. This lifespan extension requires daf-16 [11799246]. Homozygous mes-1 mutant progeny from homozygous mutant mothers are sterile [1783292].


References:
  • 11799246: Regulation of life-span by germ-line stem cells in Caenorhabditis elegans.
  • 1783292: Identification of grandchildless loci whose products are required for normal germ-line development in the nematode Caenorhabditis elegans.


    • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

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