Activating let-60 mutation

Species: Nematode (Taxid: 6239)
Factor: let-60
Manipulation: Gain-of-Function, Mutation
Effect:

The let-60(n1046gf) activating mutation greatly reduces lifespan of wild-type, weakly suppresses constitutive dauer diapause in daf-2 and age-1 mutants and extends lifespan induced by mutation of daf-2 [16164423].


References:
  • 16164423: LET-60 RAS modulates effects of insulin/IGF-1 signaling on development and aging in Caenorhabditis elegans.


  • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR



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