let-363 RNAi

Species: Nematode (Taxid: 6239)
Factor: let-363
Manipulation: Loss-of-Function, Knockdown, RNA Interference
Effect:

let-363 RNAi significantly extends the lifespan of wild-type, but does not further extend the long lifespan of eat-2 mutant [17266679]. let-363 RNAi led to an average increase in lifespan of 8% in wild-type and 3% in eat-2 background. let-363 works synergistically with eat-2 mutation. Inhibition of let-363 leads to a phenotype similar to starved animals and modest increase in lifespan [16720740]. DR fails to significantly extend lifespan of let-363 RNAi-treated animals [19079239]. RNAi of let-363 results in a doubling of lifespan. RNAi of let-363 begun at hatching extends lifespan to the same extent as RNAi begun at the first day of adulthood. RNAi of let-363 fails to further extend the lifespan of daf-2 mutants [14668850]. Lifespan extension of let-363 RNAi does not require daf-16 [14668850]. let-363 RNAi slightly extends lifespan of daf-16 mutation [16720740]. RNAi of let-363 causes many phenotypes similiar to daf-2 mutation: lipid accumulation in intestinal cells, reduced fertility, and reduced viability due to embryonic/larval arrest [14668850].

Mean: +8

References:
  • 19079239: Signalling through RHEB-1 mediates intermittent fasting-induced longevity in C. elegans.
  • 17266679: Lifespan extension by conditions that inhibit translation in Caenorhabditis elegans.
  • 16720740: daf-16 protects the nematode Caenorhabditis elegans during food deprivation.
  • 14668850: Genetics: influence of TOR kinase on lifespan in C. elegans.


  • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR



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