Denigma

let-363 mutation

Species: Nematode (Taxid: 6239)
Factor: let-363
Manipulation: Loss-of-Function, Mutation
Effect:

Mutation of let-363 results in a doubling of lifespan [14668850]. However, the let-363(h111) allele has no significant effect on lifespan [15253933]


References:
  • 15253933: The TOR pathway interacts with the insulin signaling pathway to regulate C. elegans larval development, metabolism and life span.
  • 14668850: Genetics: influence of TOR kinase on lifespan in C. elegans.


    • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

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