Denigma

Ubiquitinous SOD1 overexpression

Species: House mouse (Taxid: 10090)
Factor: SOD1
Manipulation: Gain-of-Function, Overexpression
Effect:

Ubiquitous overexpression of SOD1 does not extend lifespan in mice. Homozygous transgenic mice with two- to five-fold overexpression of SOD1 in various tissues exhibit a light reduction in lifespan. Hemizygous transgenic mice, with 1.5- to 3-fold overexpression of SOD1 display no difference in lifespan compared with nontransgenic litermate controls [10719757]. Transgenic mice with a mutant SOD1 transgene develop neuronal cytoskeletal lesions resembling the human amytrophic lateral sclerosis (ALS) phenotype [8610185]. Transgenic mice overexpressing SOD1 (and having 3.1-fold higher cellular Cu,Zn SOD activity in the brain) have reduced infarct size following experimental cerebral ischemia [1763030].


References:
  • 10719757: Ubiquitous overexpression of CuZn superoxide dismutase does not extend life span in mice.
  • 8610185: Transgenic mice carrying a human mutant superoxide dismutase transgene develop neuronal cytoskeletal pathology resembling human amyotrophic lateral sclerosis lesions.
  • 1763030: Attenuation of focal cerebral ischemic injury in transgenic mice overexpressing CuZn superoxide dismutase.


    • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

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