Denigma: Intervention

Hsp68 overexpression

Species: Fruit fly (Taxid: 7227)
Factor: Hsp68
Manipulation: Gain-of-Function, Overexpression
Effect:

Overexpression of Hsp68 extends modestly (by around 15%) median and maximum lifespan [14602080].

There is a consistent and significant lifespan extension by 20% in both males and females when hsp68 is overexpressed in somatic cells. hp68 overexpression using GMR-Gal4, and eye-specific driver that expresses Gal4 in salivary glands has no effects.Hsp78 overexpression using the weaker 5961FS driver moderately but significantly extends lifespan [20976250].

Mean: +20
Median: +15
Maximum: +15

References:

14602080: JNK signaling confers tolerance to oxidative stress and extends lifespan in Drosophila.

20976250: Lifespan extension by preserving proliferative homeostasis in Drosophila.

Aging Relevance Analysis/Source:

GenAge