Denigma: Intervention

HSP104 deletion

Species: Budding yeast (Taxid: 4932)
Factor: HSP104
Manipulation: Loss-of-Function, Knockout, Mutation, Deletion
Effect:

Deletion of HSP104 leads to a 14% [9851879] to 40% [17908928] reduction in mean replicative lifespan, therfore it is required for required for longevity. Exposure of cells to transient sub-lethal heat-stress extends mean lifespan by 12% while decreasing maximum lifespan by 14%. This effect does not occur in an HSP104 null mutant [9851879]. HSP104 null mutant is viable but displays reduced high temperature survival [8643570].

Mean: -14 to -40

References:

17908928: Accelerated aging and failure to segregate damaged proteins in Sir2 mutants can be suppressed by overproducing the protein aggregation-remodeling factor Hsp104p.

8643570: Heat-shock protein 104 expression is sufficient for thermotolerance in yeast.

9851879: Heat stress-induced life span extension in yeast.

Aging Relevance Analysis/Source:

GenAge