HAP5 deletion

Species: Budding yeast (Taxid: 4932)
Factor: HAP5
Manipulation: Loss-of-Function, Knockout, Mutation, Deletion
Effect:

Deletion of HAP5 shortens replicative lifespan by approximately 40%. This is not a premature aging phenotype as "old" HAP5 cells do not become premature sterile or exhibit other biomarkers of yeast aging [9271578]. HAP5 null mutants are unable to grow on a non-fermentable carbon source [7828851].

Mean: -40

References:
  • 9271578: Accelerated aging and nucleolar fragmentation in yeast sgs1 mutants.


  • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR



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