Denigma

GPR1 deletion

Species: Budding yeast (Taxid: 4932)
Factor: GPR1
Manipulation: Loss-of-Function, Knockout, Mutation, Deletion
Effect:

Deletion of GRP1 increases mean and maximum replicative lifespan by 41% and 26%, respectively. GRP1 deletion mutants have also longer chronological lifespan. Deletion of GPR1 extends replicative lifespan by reducing cAMP-PKA activity and provides a genetically model for DR [11000115].

Mean: +41
Maximum: +26

References:
  • 11000115: Requirement of NAD and SIR2 for life-span extension by calorie restriction in Saccharomyces cerevisiae.


    • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

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