Denigma

Homozygous Gh1 anti-sense transgene

Species: Norway rat (Taxid: 10116)
Factor: Gh1
Manipulation: Loss-of-Function, Mutation, Anti-Sense Transgene
Effect:

Animals carrying two copies of a Gh1 anti-sense transgene (tg/tg) have a slighlty shorter lifespan (by 5-10%) compared to -/- animals. tg/tg animals are dwarfs and exhibit reduced levels of serum IGF1 [12057928].

Mean: -5 to -10

References:
  • 12057928: Life span extension by reduction in growth hormone-insulin-like growth factor-1 axis in a transgenic rat model.


    • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

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