Fwd overexpression

Species: Fruit fly (Taxid: 7227)
Factor: Fwd
Manipulation:
Effect:

Overexpression of Fwd (from a doxycline-inducible promoter) increases mean lifespan by 7-9% [12620118]. Fwd regulates actin organization and ring canal formation during germline cytokinesis [10934029] by catalysing the first step in the synthesis of the key regulatory membrane phsopholipid PIP2, which is generated from PIP by a PI 4,5-kinase.

Mean: +7 to +9

References:
  • 12620118: A search for doxycycline-dependent mutations that increase Drosophila melanogaster life span identifies the VhaSFD, Sugar baby, filamin, fwd and Cctl genes.


  • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR



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