Denigma

egl-4 mutation

Species: Nematode (Taxid: 6239)
Factor: egl-4
Manipulation: Loss-of-Function, Knockout, Mutation
Effect:

Mutations in egl-4 extends lifespan by up to 55%. Lifespan extension by mutation of egl-4 is suppressed by daf-16. egl-4 mutation results in normal morphology and development, however egl-4 animals are almost twice as big as normal and have weak eff-laying defects [12571101].

Mean: +55

References:
  • 12571101: Cyclic GMP-dependent protein kinase EGL-4 controls body size and lifespan in C elegans.


    • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

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