Denigma: Intervention

daf-9 mutation

Species: Nematode (Taxid: 6239)
Factor: daf-9
Manipulation: Loss-of-Function, Mutation
Effect:

Mutations in daf-9 increase lifespan up to 52% [11740945]. Mutation of daf-9 extends mean and maximum lifespan at 15 degree Celsius by 15-75% and 28-96%, respectively [11782415]. Lifespan extension conferred by mutation of daf-9 is suppressed by mutation of daf-12, but not by mutation of daf-16. daf-3 mutation results in a wild-type lfiespan, but greatly extends the long-lived daf-9 mutant lifespan. daf-9 mutants are dauer-constitutive [3350212], exhibit gonadal cell migration defect [11782415], and a post-dauer molting defect.

Mean: +15 to +75
Maximum: +28 to +96

References:

11782415: DAF-9, a cytochrome P450 regulating C. elegans larval development and adult longevity.

11740945: A hormonal signaling pathway influencing C. elegans metabolism, reproductive development, and life span.

3350212: Mutants of Caenorhabditis elegans that form dauer-like larvae.

Aging Relevance Analysis/Source:

GenAge