Denigma

Heterozyogous fat-specific Insr knockout (FIRKO)

Species: House mouse (Taxid: 10090)
Factor: Insr
Manipulation: Loss-of-Function, Knockout, Mutation, Deletion
Effect:

Deletion of Insr specifically in adipose tissue results in a 15-18% increase in mean, median and maximum lifespan. Fat-specific insulin-receptor knockout (FIRKO) reduces fat mass and protects against age-related obesity and its subsequent metabolic abnormality, without an decrease in food intake. Both male and female FIRKO mice have an increase in mean lifespan of around 134 days (18%), with parallel increases in median and maximum lifespan. FIRKO mice consume the same amount of food on per animal basis as control littermates, but have 15-25% lower body-mass and 50-70% reduced fat mass [12543978]. Disruption of Insr in all tissues reults in neonatal lethality [8612577].

Mean: +15 to +18
Median: +15 to +18
Maximum: +15 to +18

References:
  • 12543978: Extended longevity in mice lacking the insulin receptor in adipose tissue.


    • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

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