Denigma: Intervention

CYT1 deletion

Species: Budding yeast (Taxid: 4932)
Factor: CYT1
Manipulation: Loss-of-Function, Knockout, Mutation, Deletion
Effect:

Deletion of CYT1 increases replicative lifespan by 15% in the alpha strain and decreases replicative lifespan by 20% in a strain. Deletion of CYT1 decreases replicative lifespan and cancels out replicative lifespan extension by HAP4 overexpression. Initially, it was shown that deletion of CYT1 also prevents lifespan extension by 0.5% glucose restriction [12124627], but later it was shown that either 0.5 or 0.05 % glucose restriction increases replicative lifespan of cyt1Delta cells [16311627].

References:

12124627: Calorie restriction extends Saccharomyces cerevisiae lifespan by increasing respiration.

16311627: Increased life span due to calorie restriction in respiratory-deficient yeast.

Aging Relevance Analysis/Source:

GenAge