Denigma: Intervention

che-2 mutation

Species: Nematode (Taxid: 6239)
Factor: che-2
Manipulation: Loss-of-Function, Knockout, Mutation, Deletion
Effect:

che-2 recessive loss-of-function mutations extend lifespan up to 50% (in Bristol N2) [10617200]. che-2 mutants are chemotactic defective, slightly small, defective for osmotic avoidance, have ciliated neurons with abnormal stunted ultrastructure, and are dauer defective [2428682; 1732156].

Mean: +50

References:

10617200: Regulation of lifespan by sensory perception in Caenorhabditis elegans.

1732156: Genetic analysis of chemosensory control of dauer formation in Caenorhabditis elegans.

Aging Relevance Analysis/Source:

GenAge