Denigma

ife-2 mutation

Species: Nematode (Taxid: 6239)
Factor: ife-2
Manipulation: Loss-of-Function, Knockout, Mutation
Effect:

Loss-of-function mutation in ife-2 reduces protein synthesis and increases maximum lifespan by about 20%. It does not extend the lifespan of daf-16(RNAi) animals. TOR/let-373 RNA interference further extends lifespan of ife-2 mutants. Reduction of protein synthesis increases ATP availability and stress resistance [17266679].

Maximum: +20

References:
  • 17266679: Lifespan extension by conditions that inhibit translation in Caenorhabditis elegans.


    • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

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