Denigma

ctbp-1 mutation

Species: Nematode (Taxid: 6239)
Factor: ctbp-1
Manipulation: Loss-of-Function, Knockout, Mutation, Deletion
Effect:

Genetic inactivation of ctbp-1 results in lifespan extension dependent on daf-16, but independent of sir-2.1. RNAi of lips-7(C09E8.2) suppresses lifespan extension by ctbp-1 inactivation [19164523].


References:
  • 19164523: The conserved NAD(H)-dependent corepressor CTBP-1 regulates Caenorhabditis elegans life span.


    • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

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