Denigma: Intervention

ins-7 RNAi

Species: Nematode (Taxid: 6239)
Factor: ins-7
Manipulation: Loss-of-Function, Knockdown, RNA Interference
Effect:

RNA interference of ins-7 extends the mean lifespan by 55% at 20 degree Celsius in N2 rrf-3(pk1426) [12845331]. ins-7 RNAi significantly extends lifespan under AL. Glucose suppresses the extended lifespan by ins-7 RNAi [19883616]. RNAi of ins-7 does not further extend the lifespan in daf-2 mutants [12845331]. ins-7 is repressed in animals with reduced daf-2 activity and elevuated in animals with reduced daf-16 activity.

Mean: +55

References:

12845331: Genes that act downstream of DAF-16 to influence the lifespan of Caenorhabditis elegans.

19883616: Glucose shortens the life span of C. elegans by downregulating DAF-16/FOXO activity and aquaporin gene expression.

Aging Relevance Analysis/Source:

GenAge