Similar to daf-16 and hsf-1 mutants, aqp-1 mutants were short-lived, and their short lifespan was not further decreased by glucose. Overexpression of aqp-1::GFP rescued short lifespan of aqp-1 deletion mutants and partially prevented glucose from shortening lifespan. aqp-1 mutation does not further decrease the short lifespan of daf-16 and/or hsf-1 mutants. Dietary glucose does not cause significant differences in levels of glucose or glycerol in wild-type vs. aqp-1 mutants [19883616].
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