Denigma

phb-2 RNAi

Species: Nematode (Taxid: 6239)
Factor: phb-2
Manipulation: Loss-of-Function, Knockdown, RNA Interference
Effect:

phb-2 RNAi shortens lifespan of wild type, aak-2, cep-1 (p53) and jnk-1 mutants, but increases lifespan of daf-2, daf-7, daf-4, daf-11, gas-1, mev-1, isp-1, clk-1, nhr-49, fat-7, gld-1 mutants. daf-16 mutation fully suppressed exceptionally long-lifespan of via RNAi prohibitin-depleted, daf-2 mutants [19812672].


References:
  • 19812672: Prohibitin couples diapause signalling to mitochondrial metabolism during ageing in C. elegans.


    • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

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