trx-1 mutation

Species: Nematode (Taxid: 6239)
Factor: trx-1
Manipulation: Loss-of-Function, Knockout, Mutation, Deletion
Effect:

Mutants with a deletion in the trx-1 gene display a decrease in lifespan and are sensitive to oxidative stress [16324156]. trx-1 null mutant display reduced mean and maximum lifespan. trx-1 deletion completely suppresses the lifespan extension caused by eat-2 mutation, but only partially suppresses that by daf-2 or osm-5 mutations [16387300].


References:
  • 16387300: Lifespan decrease in a Caenorhabditis elegans mutant lacking TRX-1, a thioredoxin expressed in ASJ sensory neurons.


  • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR



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