Heterzygous chico mutation

Species: Fruit fly (Taxid: 7227)
Factor: chico
Manipulation: Loss-of-Function, Knockout, Mutation
Effect:

Mutation in chico extends mean, median and maximum lifespan by 44%, 36% and 35% in heterozygotes. chico mutation produces dwarf, long-lived females at normal nutrition [11292874]. Wild-type and chico mutant females have similar peak lifespan under DR, but the food concentration at which these are achieved is shifted to higher amounts. chico mutation induces a state equivalent to submaximal, DR-induced slowing of aging [11951037]. Male chico heterozygous live 13% longer than wild-type [11292874]. chico heterzoygous females have a reduced fecundity. chico heterozygous mutants are resistant to starvation but not oxidative stress or temperature stress [11292874].

Mean: +44
Median: +36
Maximum: +35

References:
  • 11292874: Extension of life-span by loss of CHICO, a Drosophila insulin receptor substrate protein.
  • 11951037: Dietary restriction in long-lived dwarf flies.


  • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR



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