Denigma

Constitutive active S6k overexpression

Species: Fruit fly (Taxid: 7227)
Factor: S6k
Manipulation: Gain-of-Function, Overexpression, Mutation
Effect:

Overexpression of a constitutively active form of S6k (alias dS6K) decreases mean lifespan by 34% at 29°C [15186745].

Mean: -34

References:
  • 15186745: Regulation of lifespan in Drosophila by modulation of genes in the TOR signaling pathway.


    • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR
    • Comparisons:
  • da-GAL4/UAS-dS6kSTDETE vs. +/da-GAL4 : -38.5(mean) -22.6(max) <0.0001(p-value)

    • Edit / Update (Admin) | Delete

    Comment on This Data Unit